12/3/2023 0 Comments Emily demeo![]() ![]() The prevalence of PRISm in COPDGene is 12.3%. To explore potential subgroups within PRISm, we performed unsupervised k-means clustering. ![]() To investigate common genetic predictors of PRISm, we performed a genome-wide association study (GWAS). To identify epidemiological and radiographic predictors of PRISm, we performed univariate and multivariate analyses comparing PRISm subjects both to control subjects with normal spirometry and to subjects with COPD. Studies investigating quantitative chest tomographic features, genetic associations, and subtypes in PRISm subjects have not been reported.ĭata from current and former smokers enrolled in COPDGene (n = 10,192), an observational, cross-sectional study which recruited subjects aged 45-80 with ≥10 pack years of smoking, were analyzed. Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. ![]() James D Crapo, Edwin K Silverman, Barry J Make, Elizabeth A Regan, Stephanie Bratschie, Rochelle Lantz, Sandra Melanson, Lori Stepp, Terri Beaty, Russell P Bowler, James D Crapo, Jeffrey L Curtis, Douglas Everett, Meilan K Han, John E Hokanson, David Lynch, Barry J Make, Elizabeth Regan, Edwin K Silverman, E Sutherland, Eugene R Bleecker, Harvey O Coxson, Ronald G Crystal, James C Hogg, Michael A Province, Stephen I Rennard, Duncan Thomas, Thomas Croxton, Weiniu Gan, Lisa Postow, John W Walsh, Randel Plant, Delia Prieto, Douglas Everett, Andre Williams, Ruthie Knowles, Carla Wilson, John Hokanson, Jennifer Black-shinn, Gregory Kinney, Terri Beaty, Peter J Castaldi, Michael Cho, Dawn L DeMeo, Marilyn G Foreman, Nadia N Hansel, Megan E Hardin, Craig Hersh, John E Hokanson, Nan Laird, Sharon M Lutz, Manuel Mattheisen, Merry-Lynn McDonald, Margaret M Parker, Elizabeth A Regan, Stephanie Santorico, Edwin K Silverman, Emily S Wan, Jin Zhou, Terri Beaty, Craig P Hersh, Edwin K Silverman, David Lynch, Mustafa Al Qaisi, Jaleh Akhavan, Christian W Cox, Harvey O Coxson, Deanna Cusick, Jennifer G Dy, Shoshana Ginsburg, Eric A Hoffman, Philip F Judy, Alex Kluiber, Alexander McKenzie, John D Newell Jr, John J Reilly Jr, James Ross, Raul San Jose Estepar, Joyce D Schroeder, Jered Sieren, Arkadiusz Sitek, Douglas Stinson, Edwin van Beek, George R Washko, Jordan Zach, Robert Jensen, E Sutherland, Homayoon Farzadegan, Samantha Bragan, Stacey Cayetano, Jeffrey Curtis, Ella Kazerooni, Nicola Hanania, Philip Alapat, Venkata Bandi, Kalpalatha Guntupalli, Elizabeth Guy, Antara Mallampalli, Charles Trinh, Mustafa Atik, Hasan Al-Azzawi, Marc Willis, Susan Pinero, Linda Fahr, Arun Nachiappan, Collin Bray, L Frigini, Carlos Farinas, David Katz, Jose Freytes, Anne Marie Marciel, Dawn DeMeo, Craig Hersh, George Washko, Francine Jacobson, Hiroto Hatabu, Peter Clarke, Ritu Gill, Andetta Hunsaker, Beatrice Trotman-Dickenson, Rachna Madan, R Barr, Byron Thomashow, John Austin, Belinda D'Souza, Neil MacIntyre Jr, H McAdams, Richard Rosiello, Timothy Bresnahan, Joseph Bradley, Steven Meller, Suzanne Roland, Charlene McEvoy, Joseph Tashjian, Robert Wise, Nadia Hansel, Robert Brown, Gregory Diette, Karen Horton, Richard Casaburi, Janos PORSZASZ, Hans Fischer, Matt Budoff, Mehdi Rambod, Michael E DeBakey, Amir Sharafkhaneh, Charles Trinh, Hirani Kamal, Roham Darvishi, Marc Willis, Susan Pinero, Linda Fahr, Arun Nachiappan, Collin Bray, L Frigini, Carlos Farinas, David Katz, Jose Freytes, Anne Marie Marciel, Dennis Niewoehner, Quentin Anderson, Kathryn Rice, Audrey Caine, Marilyn Foreman, Eugene Berkowitz, Russell Bowler, David Lynch, Joyce Schroeder, Valerie Hale, John Armstrong 3rd, Jonathan Chung, Gerard Criner, Victor Kim, Nathaniel Marchetti, Aditi Satti, A Mamary, Robert Steiner, Chandra Dass, Libby Cone, William Bailey, Mark Dransfield, Michael Wells, Surya Bhatt, Hrudaya Nath, Satinder Singh, Joe Ramsdell, Paul Friedman, Alejandro Cornellas, John Newell Jr, Edwin J R van Beek, Fernando Martinez, Meilan Han, Ella Kazerooni, Christine Wendt, Tadashi Allen, Frank Sciurba, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Danielle Hooper, Sandra Adams, Carlos Orozco, Mario Ruiz, Amy Mumbower, Ariel Kruger, Carlos Restrepo, Michael Lane
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